I have always had an issue with how quickly Methadone metabolizes in his system and even at a 180mg dose would only hold him up to 20-22 hours. This list is not exhaustive: Milk thistle might increase how quickly the liver breaks down some medications. Milk thistle (Silybum marianum) is an herbal remedy widely used in HIV-infected patients for the treatment or prevention of liver disease caused by hepatitis and hepatotoxic drugs. Milk thistle may raise the levels of a hepatotoxic metabolite of pyrazinamide. "Is there a drug interactions between milk thistle and pomegranate?" "what do you suggest if my father takes lamivudine and tenofovir for his liver. If you use protease inhibitors or non-nukes, and take a milk thistle, it may raise levels of these drugs, causing side effects. Does Milk Thistle Interfere With Blood Pressure Medication Hep What Does C. Hepatic synthetic and genetically destroyed Can have high death rates for Asian American groups are several times higher than 80% with medical management 2009, 8:709714 Andrade RJ, Robles M, Lucena MI. The phase IV clinical study is created by eHealthMe based on reports of 232 people who take Milk thistle and Metformin from the FDA, and is updated regularly. It seems my dose has been holding him better, meaning a full 24 hours. This document does not contain all possible interactions. Conclusions: HP (especially ginseng, rhadiola rosea, ginkgo biloba, milk thistle) are associated with a significant risk of pharmacokinetic and pharmacodynamic interactions with psychotropic drugs. Milk thistle (Silybum marianum) is a medicinal plant that has been used for more than 2,000 years in traditional herbal medicine. Antiplatelet and anticoagulant drugs (blood thinners). Medications used for lowering cholesterol (Statins)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider. Some … However, little conclusive information is available about milk thistle interactions. Early research suggests that milk thistle may decrease the activity of certain liver enzymes. Milk thistle and drug interactions are common problems, but can easily be prevented if you take a look at the 3 main medications that you should NOT mix milk thistle with! Drugs broken down by the liver. Drug interactions are reported among people who take Milk thistle and Metformin. Milk thistle may reduce your blood sugar, so it needs to be used with caution as it may trigger hypoglycemia (low blood sugar) in people on diabetes medications. Drugs for high cholesterol. Compounds found in milk thistle – sylibin, sylimarin – act as antioxidants and also stimulate the repair of the liver. Also question is, what medications does milk thistle interfere with? It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Milk thistle can interact with certain drugs, so check with your GP or a medical herbalist before taking. This study is also expected to take approximately 8 weeks but will involve 18 clinic visits. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. The commonly used herbal supplements selected include Echinacea, Ginkgo biloba, garlic, St. John's wort, goldenseal, and milk thistle. Milk thistle may interact with other drugs. 30 July 2001. The HCV Advocate says that the lipid-lowering drugs Lescol, Mevacor, Pravachol, Zocor and Baycol all have the potential to interact with milk thistle in this way. Milk Thistle received an overall rating of 0 out of 10 stars from 0 reviews. A 44-year-old member asked: Is there a drug interactions between milk thistle and pomegranate? Please consult a doctor or healthcare professional before trying any remedies. Blood pressure is defined as the pressure pushed against artery walls as a result of the heart pumping blood. This excess of drugs could lead to uncomfortable or even dangerous side effects. Anti-anxiety drugs. do these drugs interact with milk thistle?" does milk thistle interfere with any prescription drugs. A few include: Cholesterol-lowering medications; Allergy medications; Blood-thinning medications; Some forms of cancer treatment; Anti-anxiety medications; Milk thistle may also be a problem with hormonal birth control, hormone replacement therapy, seizure medications, … If possible, wait four hours after you take your meds until you take the milk thistle. Milk thistle may excessively lower blood sugar in people on antidiabetic drugs. 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